M. S. Savinov, O. Griaznova, G. V. Tikhonowski, A. A. Popov, I. N. Zavestovskaya, S. M. Klimentov, A. V. Kabashin
- National Research Nuclear University MEPhI, Institute for Physics and Engineering in Biomedicine, 115409, Moscow, Russia
- Skolkovo Institute of Science and Technology, Center for Photonic Science and Engineering, 121205, Moscow, Russia
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
- Lebedev Physical Institute, Russian Academy of Sciences, 119991, Moscow, Russia
- LP3, Aix Marseille University, CNRS, 13288 Marseille, France
Abstract: The possibility of using elemental bismuth nanoparticles as sensitizers for radiation therapy and computed tomography contrast agents is investigated. A comparative analysis of the X-ray contrast properties of bismuth nanoparticles with classical gold nanoparticles and bismuth oxychloride nanosheets is carried out. It is shown that laser-synthesized bismuth nanoparticles demonstrate higher X-ray contrast efficiency compared to traditional gold nanoparticles; they also have X-ray contrast properties similar to those of chemically synthesized analogues based on bismuth oxychloride nanosheets. Unique physicochemical characteristics in combination with high radiopaque properties of laser-synthesized bismuth nanoparticles form a new promising alternative to traditional sensitizers for radiation theranostics of oncological diseases.
Keywords: bismuth, nanoparticles, computed tomography, laser ablation in liquids, nanomedicine.
Received: 17.07.2023
Revised: 09.08.2023